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Genitourinary Syndrome of Menopause (GSM): A Clear Guide

Genitourinary Syndrome of Menopause, or GSM, is the medical term for the group of vaginal, vulvar and urinary changes caused by lower estrogen during and after menopause. It used to be called vulvovaginal atrophy. The newer name reflects that it affects the bladder and urethra as well as the vagina.

Smiling woman in a gray cardigan after menopause, illustrating genitourinary syndrome of menopause

How common is GSM?

Very common. The Menopause Society estimates that GSM affects roughly 27% to 84% of postmenopausal women, yet it is frequently underdiagnosed and undertreated [1]. Unlike hot flashes, GSM tends to be progressive: without treatment, symptoms usually continue or worsen over time.

Symptoms of GSM

  • Vaginal: dryness, burning, irritation and reduced lubrication
  • Sexual: pain with intercourse, reduced arousal, and spotting after sex
  • Urinary: urgency, frequency, burning with urination and recurrent UTIs
  • Vulvar: itching, thinning skin and sensitivity

What changes in the tissue

Before menopause, estrogen keeps the vaginal lining thick and multi-layered, with a rich blood supply and natural moisture. After menopause the lining becomes thinner and flatter, blood flow drops and natural secretions decrease. That’s why dryness, irritation and discomfort become more common.

Illustration of premenopausal vaginal tissue with a thick epithelium, dense blood supply and natural moisture
Before menopause: thick lining, dense blood supply, natural moisture
Illustration of postmenopausal vaginal tissue with a thinner epithelium, reduced blood supply and less moisture
After menopause: thinner lining, reduced blood supply, less moisture

Perimenopause: it can start earlier than you think

Estrogen begins to fluctuate and decline years before your final period. Some women notice dryness or discomfort during sex in their 40s, even while they still have regular cycles. Read more in our guide to vaginal dryness in perimenopause.

GSM treatment: what works

GSM is very treatable. According to The Menopause Society and the 2025 AUA/SUFU/AUGS guideline, treatment follows a step-by-step approach based on how bothersome symptoms are [1].

  1. Hormone-free first steps: a vaginal moisturizer every 2–3 days and a lubricant during sex.
  2. Low-dose vaginal estrogen: cream, insert or ring. The most studied option for moderate to severe GSM, and it also helps prevent recurrent UTIs.
  3. Other prescriptions: vaginal DHEA (prasterone) or ospemifene, a daily pill.
  4. Pelvic floor physical therapy for painful sex or tight muscles.

Unlike hot flashes, GSM usually doesn’t go away on its own, so ongoing care is common. See the full rundown of every vaginal dryness treatment.

Hormone-free intimate comfort

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Is GSM the same as vaginal atrophy?

GSM is the newer, broader term. It includes the vaginal changes once called atrophy plus related urinary and vulvar symptoms.

Can GSM be reversed?

Symptoms can often improve a lot with consistent care. Since the underlying hormone change continues, most women need ongoing maintenance.

What are the symptoms of GSM?

Common symptoms include vaginal dryness, burning or itching, pain during sex, light bleeding after sex, urinary urgency or frequency, and repeated urinary tract infections. They can start in perimenopause and often get worse over time without treatment.

What is the treatment for GSM?

Treatment usually starts with vaginal moisturizers and lubricants. For moderate to severe symptoms, low-dose vaginal estrogen, vaginal DHEA or ospemifene are recommended. Pelvic floor physical therapy helps with painful sex.

Related reading

Sources

  1. The North American Menopause Society. The 2020 genitourinary syndrome of menopause position statement. Menopause. 2020;27(9):976–992.
  2. The Menopause Society. MenoNote: Genitourinary Syndrome of Menopause.